Medicinal Cannabis Studies
General:
Anxiety:
- Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action. (PubMed2008)
- Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug(PubMed)
- Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa (PubMed)
- Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients (PubMed)
- Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder (PubMed)
- Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation (PubMed)
- Effects of cannabidiol (CBD) on regional cerebral blood flow (PubMed)
- The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors (PubMed)
- Plant-based medicines for anxiety disorders, part 2: A review of clinical studies with supporting preclinical evidence (PubMed)
Alzheimer’s:
- The therapeutic potential of the endocannabinoid system for Alzheimer’s disease(PubMed)
- Endocannabinoid signalling in Alzheimer’s disease (PubMed)
- A molecular link between the active component of marijuana and Alzheimer’s disease pathology (PubMed)
- Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells (PubMed)
- The Potential Therapeutic Effects of THC on Alzheimer’s Disease (PubMed)
- Cannabinoids for the treatment of dementia (PubMed)
- Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression (PubMed)
- Cannabidiol: A promising drug for neurodegenerative disorders? (PubMed)
- Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer’s disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition(PubMed)
- The role of the endocannabinoid system in Alzheimer’s disease: facts and hypotheses (PubMed)
- The role of phytochemicals in the treatment and prevention of dementia (PubMed)
- Cannabinoids for the treatment of dementia (PubMed)
- Cannabidiol Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression in SHSY5YAPP+ Cells Through PPARγ Involvement (PubMed)
- Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic (Pub Med)
- Can Marijuana Prevent Alzheimer’s? (Next Avenue)
Addiction:
- Cannabidiol reduces cigarette consumption in tobacco smokers (PubMed)
- Cannabidiol inhibits the reward-facilitating effect of morphine(PubMed)
- Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances(PubMed)
- Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats(PubMed)
- Impact of Cannabis Use during Stabilization on Methadone Maintenance Treatment(PubMed)
- Impact of Cannabis Use during Stabilization on Methadone Maintenance Treatment(PubMed)
- Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents (PubMed)
- Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity (PubMed)
- Transdermal delivery of cannabidiol attenuates binge alcohol-induced neurodegeneration in a rodent model of an alcohol use disorder (ScienceDirect)
- Cannabidiol for the treatment of cannabis withdrawal syndrome (PubMed)
- Cannabis use disorders are comparatively prevalent among nonwhite racial/ethnic groups and adolescents: a national study (PubMed)
ADD/ADHD:
- Searching for a Neurobiological Basis for Self-Medication Theory in ADHD Comorbid With Substance Use Disorders (Pub Med)
- Cannabidiol and clozapine reverse MK-801-induced deficits in social interaction and hyperactivity in Sprague-Dawley rats(PubMed)
- Subtypes of Attention Deficit — Hyperactivity Disorder (ADHD) and cannabis use (PubMed)
- Childhood and current ADHD symptom dimensions are associated with more severe cannabis outcomes in college students (PubMed)
- Oral delta 9-tetrahydrocannabinol improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition: A case report(PubMed)
- Fitness to drive in spite (because) of THC (PubMed)
AIDS:
ALS:
Anorexia:
Antibiotic resistance:
Arthritis:
- Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis (PubMed)
- The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis (PubMed)
- Involvement of the endocannabinoid system in osteoarthritis pain (PubMed)
- The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55 (PubMed)
Atherosclerosis:
Asthma:
- The role of cannabinoids in inflammatory modulation of allergic respiratory disorders, inflammatory pain and ischemic stroke(PubMed)
- Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma (PubMed)
- Activation of cannabinoid receptors prevents antigen-induced asthma-like reaction in guinea pigs (PubMed)
- Endogenous cannabinoid receptor agonists inhibit neurogenic inflammations in guinea pig airways (PubMed)
- Bronchodilator effect of delta1-tetrahydrocannabinol (PubMed)
Autism:
- Mutations found in individuals with autism interfere with endocannabinoid signaling in the brain (Science Daily)
- Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders (PubMed)
- A novel approach to the symptomatic treatment of autism (Lester Grinspoon M.D., O’Shaughnessy’s)
- Targeting the endocannabinoid system in the treatment of fragile X syndrome (PubMed)
Bipolar:
Cancer Studies:
- Cannabidiol as potential anticancer drug (PubMed)
- Cannabidiol inhibits angiogenesis by multiple mechanisms (PubMed)
- The inhibitory effects of cannabidiol on systemic malignant tumors (PubMed)
- Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1 (PubMed)
- Marijuana fights cancer and helps manage side effects (Daily Beast)
- Endocannabinoids in endocrine and related tumours (PubMed)
- A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells (PubMed)
- TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer (PubMed)
- Cannabis and Cannabinoids (PDQ®)Laboratory/Animal/Preclinical Studies (Natinal Cancer Institute)
- Cannabinoids: potential anticancer agents Manuel Guzmán
Lung Cancer:
- Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1C (PubMed)
- COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells (PubMed)
- Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells (PubMed)
- Media ignored expert’s shocking findings that marijuana helps prevent lung cancer(O’Shaughnessy’s)
Prostate / Colon Cancer:
- Towards the use of non-psychoactive cannabinoids for prostate cancer (PubMed)
- In Vitro Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines (Scirp.org)
- Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent (PubMed)
- Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer (PubMed)
- Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol (PubMed)
Breast Cancer:
- Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma (PubMed)
- Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy (PubMed)
- Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis (PubMed)
- Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells (PubMed)
- Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration (PubMed)
- Cannabis and Cannabinoids (PDQ®)Laboratory/Animal/Preclinical Studies (Natinal Cancer Institute)
Glioblastoma / Brain:
- Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival (PubMed)
- Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines (PubMed)
- Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas (PubMed)
- Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism (PubMed)
- Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target (PubMed)
- Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents (PubMed)
- Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect (PubMed)
- Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme (PubMed)
- The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model
Leukemia:
Skin Cancer:
Kaposi Sarcoma:
Cancer ralated pain:
- Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain (PubMed)
- Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial (PubMed)
- Marijuana extract helps prevent chemo pain (UPI)
Chron's & Stomach Problems :
- Cannabidiol in inflammatory bowel diseases: a brief overview (PubMed)
- Cannabis finds its way into treatment of Crohn’s disease (PubMed)
- Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis (PubMed)
- Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis (PubMed)
- The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis (PubMed)
- Topical and systemic cannabidiol improves trinitrobenzene sulfonic acid colitis in mice (PubMed)
- Cannabinoids and the gut: New developments and emerging concepts (PubMed)
- Endocannabinoids and the gastrointestinal tract (PubMed)
- Cannabinoids and gastrointestinal motility: Animal and human studies (PubMed)
- Hergenrather presents study of Crohn’s patients as a template for clinical research on Cannabis (O’Shaughnessy’s)
Depression :
- Endocannabinoid system dysfunction in mood and related disorders (PubMed)
- Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa (PubMed)
- The endocannabinoid system and the treatment of mood and anxiety disorders(PubMed)
- Endocannabinoid signaling in the etiology and treatment of major depressive illness (PubMed)
- Antidepressant-like effects of cannabidiol in mice: Possible involvement of 5-HT1A receptors (PubMed)
- Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants (PubMed)
- Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa (PubMed)
- Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress (PubMed)
- Serum contents of endocannabinoids are correlated with blood pressure in depressed women (PubMed)
- The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants (PubMed)
- Antidepressants and Changes in Concentration of Endocannabinoids and N-Acylethanolamines in Rat Brain Structures (PubMed)
Diabetes:
- The impact of marijuana use on glucose, insulin, and insulin resistance among US adults (American Journal of Medicine)
- Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy(PubMed)
- Cannabidiol lowers incidence of diabetes in non-obese diabetic mice (PubMed)
- Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes (PubMed)
- Cannabidiol arrests onset of autoimmune diabetes in NOD mice (PubMed)
- Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation (PubMed)
- Cannabinoids alter endothelial function in the Zucker rat model of type 2 diabetes(PubMed)
- The endocannabinoid system in obesity and type 2 diabetes (PubMed)
- Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes(PubMed)
- The endocannabinoid system and plant-derived cannabinoids in diabetes and diabetic complications (PubMed)
- Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain(PubMed)
- Biochemical and immunohistochemical changes in delta-9-tetrahydrocannabinol-treated type 2 diabetic rats (PubMed)
Endocrine disorders:
- Endocannabinoid system participates in neuroendocrine control of homeostasis (PubMed)
- The emerging role of the endocannabinoid system in endocrine regulation and energy balance (PubMed)
- Endocannabinoids in endocrine and related tumours (PubMed)
- Role of the endocannabinoid system in food intake, energy homeostasis and regulation of the endocrine pancreas (PubMed)
- The role of the endocannabinoid system in the neuroendocrine regulation of energy balance (PubMed)
Epilepsy/seizure:
- CBD for children with Dravet’s and intractable seizures (Video)
- Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy (PubMed)
- Medicinal marijuana stops seizures, brings hope to a little girl (Gazette, Colorado Springs)
- Cannabinoids for epilepsy (PubMed)
- Cannabis, cannabidiol, and epilepsy – From receptors to clinical response (PubMed)
- The non-psychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability (ACS Publications)
- Chronic administration of cannabidiol to healthy volunteers and epileptic patients (PubMed)
- Endocannabinoid system protects against cryptogenic seizures (PubMed)
- Seizing an opportunity for the endocannabinoid system (Pub Med)
- Cannabidiol: promise and pitfalls (Pub Med)
- Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders (PubMed)
- Report of a parent survey of cannabidiol-enriched cannabis use in pediatrictreatment-resistant epilepsy (Epilepsy Association of Utah)
- From the Editors: Cannabidiol and medical marijuana for the treatment of epilepsy (PubMed)
- Cannabidivarin (CBDV) suppressespentylenetetrazole (PTZ)-inducedincreases in epilepsy-related gene expression (PubMed)
- Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures (PubMed)
- Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo (PubMed)
- Hypnotic and antiepileptic effects of cannabidiol (PubMed)
- The cannabinoids as potential antiepileptics (PubMed)
- Cannabidiol–antiepileptic drug comparisons and interactions in experimentally induced seizures in rats (PubMed)
Fibryomalgia:
- Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? (PubMed)
- Cannabis use in patients with fibromyalgia: effect on symptoms relief and health-related quality of life (PubMed)
Glaucoma:
Heart Disease:
- Is the cardiovascular system a therapeutic target for cannabidiol? (PubMed)
- Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion (PubMed)
- Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy(PubMed)
- The Effect of Cannabidiol on Ischemia/Reperfusion-Induced Ventricular Arrhythmias: The Role of Adenosine A1 Receptors (PubMed)
- Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury (PubMed)
- Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension (PubMed)
- Oleamide: A fatty acid amide signaling molecule in the cardiovascular system?(PubMed)
Huntington’s:
- Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington’s disease (PubMed)
- Cannabinoids: Novel medicines for the treatment of Huntington’s disease (PubMed)
- Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington’s disease: role of CB(1) and CB(2) receptors (PubMed)
- Controlled clinical trial of cannabidiol in Huntington’s disease (PubMed)
- Prospects for cannabinoid therapies in basal ganglia disorders (PubMed)
- Neuroprotective Properties of Cannabigerol in Huntington’s Disease: Studies in R6/2 Mice and 3-Nitropropionate-lesioned Mice (PubMed)
Inflamation:
- Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress (PubMed)
- The endocannabinoid system: an emerging key player in inflammation (PubMed)
- Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice (PubMed)
- Cannabinoids, endocannabinoids, and related analogs in inflammation (PubMed)
- Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor (PubMed)
- Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors (PubMed)
- Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis (PubMed)
- Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation (PubMed)
- Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement (PubMed)
- Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption (PubMed)
- Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation(PubMed)
- Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death (PubMed)
- Cannabinoids in clinical practice (PubMed)
Irritable Bowel:
- Cannabidiol in inflammatory bowel diseases: A brief overview (PubMed)
- Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis (PubMed)
- Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? (PubMed)
- Cannabinoid actions at TRPV channels: Effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation (PubMed)
- Therapeutic potential of cannabinoid-based drugs (PubMed)
- Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease (Biochemical Pharmacology) (PubMed)
- Cannabinoids and the gut: New developments and emerging concepts (PubMed)
- Endocannabinoids and the gastrointestinal tract (PubMed)
Kidney Disease:
Liver Disease:
- The endocannabinoid system and liver diseases (PubMed)
- Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death (PubMed)
- Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis (PubMed)
- Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats (PubMed)
- Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol (PubMed)
- Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice (PubMed)
- Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation (PubMed)
Metabolic Syndrome:
Migraine:
- Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? (PubMed)
- Effects of anandamide in migraine: data from an animal model (PubMed)
- Cannabinoids and hallucinogens for headache (PubMed)
- The endocannabinoid system and migraine (PubMed)
- Variations in the cannabinoid receptor 1 gene predispose to migraine (PubMed)
Mood Disorders:
- Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders (PubMed)
- The endocannabinoid system and the treatment of mood and anxiety disorders(PubMed)
- The endocannabinoid system and psychiatric disorders (PubMed)
- The endocannabinoid system in the regulation of emotions throughout lifespan: A discussion on therapeutic perspectives (PubMed)
- Endocannabinoid system dysfunction in mood and related disorders (PubMed)
- Effects of cannabidiol (CBD) on regional cerebral blood flow (PubMed)
Motion Sickness:
Multiple Sclerosis (MS):
- Sativex for the management of multiple sclerosis symptoms (PubMed)
- THC and CBD oromucosal spray (Sativex®) in the management of spasticity associated with multiple sclerosis (PubMed)
- Clinical efficacy and effectiveness of Sativex, a combined cannabinoid medicine, in multiple sclerosis-related spasticity (PubMed)
- Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors(PubMed)
- Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: An uncontrolled, open-label, 2-year extension trial (PubMed)
- Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: An uncontrolled, open-label, 2-year extension trial (PubMed)
- Nabiximols in the treatment of spasticity, pain and urinary symptoms due to multiple sclerosis (PubMed)
- Sativex long-term use: An open-label trial in patients with spasticity due to multiple sclerosis (PubMed)
- A double-blind, randomized, placebo-controlled, parallel-group study of Sativex, in subjects with symptoms of spasticity due to multiple sclerosis (PubMed)
- Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain (PubMed)
- Sativex: Clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain (PubMed)
Nausea:
- Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system (PubMed)
- Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus (PubMed)
- Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation (PubMed)
- Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews (PubMed)
- Regulation of nausea and vomiting by cannabinoids (PubMed)
- Cannabidiol, a non-psychoactive component of cannabis and its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats (PubMed)
- Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting (PubMed)
Neurodegeneration:
- Cannabidiol: A promising drug for neurodegenerative disorders? (PubMed)
- Cannabidiol for neurodegenerative disorders: Important new clinical applications for this phytocannabinoid? (PubMed)
- Transdermal delivery of cannabidiol attenuates binge alcohol-induced neurodegeneration in a rodent model of an alcohol use disorder (PubMed)
- Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders (PubMed)
- Cannabidiol normalizes caspase 3, synaptophysin, and mitochondrial fission protein DNM1L expression levels in rats with brain iron overload: implications for neuroprotection (Pub Med)
Neuropathic pain:
- Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain (PubMed)
- Sativex: Clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain (PubMed)
- Cannabis, pain, and sleep: Lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine (PubMed)
- Sativex successfully treats neuropathic pain characterised by allodynia: A randomised, double-blind, placebo-controlled clinical trial (PubMed)
- Cannabinoids for neuropathic pain (PubMed)
- Neuropathic orofacial pain: Cannabinoids as a therapeutic avenue (PubMed)
- Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial (PubMed)
- The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain (PubMed)
- Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation (PubMed)
- Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1A receptors without diminishing nervous system function or chemotherapy efficacy (PubMed)
- Antihyperalgesic effect of a Cannabis sativa extract in a rat model of neuropathic pain: Mechanisms involved (PubMed)
- Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action (PubMed)
- Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors (PubMed)
- Role of the cannabinoid system in pain control and therapeutic implications for the management of acute and chronic pain episodes (PubMed)
- Cannabinoids in the management of difficult to treat pain (PubMed)
- Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain (PubMed)
- Marijuana extract helps prevent chemo pain (UPI)
- Pot users less likely to take painkillers (American News Report)
Obesity:
- The impact of marijuana use on glucose, insulin, and insulin resistance among US adults (PubMed)
- Cannabinol and cannabidiol exert opposing effects on rat feeding patterns (PubMed)
- Cannabis and Δ9-tetrahydrocannabinol (THC) for weight loss? (PubMed)
- The endocannabinoid system in obesity and type 2 diabetes (PubMed)
- Role of the endocannabinoid system in abdominal obesity and the implications for cardiovascular risk (PubMed)
- Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes (PubMed)
OCD:
Osteporosis:
- Cannabinoid receptors as target for treatment of osteoporosis: A tale of two therapies (PubMed)
- Cannabinoids and bone: Friend or foe? (PubMed)
- Cannabinoid receptor type 1 protects against age-related osteoporosis by regulating osteoblast and adipocyte differentiation in marrow stromal cells(PubMed)
- Cannabinoids and the skeleton: From marijuana to reversal of bone loss (PubMed)
- The endovanilloid/endocannabinoid system: A new potential target for osteoporosis therapy (PubMed)
- The endovanilloid/endocannabinoid system in human osteoclasts: Possible involvement in bone formation and resorption (PubMed)
- Endocannabinoids and the regulation of bone metabolism (PubMed)
- Cannabinoid receptors and the regulation of bone mass (PubMed)
- Natural products as alternative treatments for metabolic bone disorders and for maintenance of bone health (PubMed)
- Peripheral cannabinoid receptor, CB2, regulates bone mass (PubMed)
- Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors (PubMed)
- Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis (PubMed)
- Skeletal lipidomics: Regulation of bone metabolism by fatty acid amide family(PubMed)
Parkinsons:
- Prospects for cannabinoid therapies in basal ganglia disorders (PubMed)
- Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson’s disease: Importance of antioxidant and cannabinoid receptor-independent properties (PubMed)
- Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson’s disease (PubMed)
- Cannabidiol can improve complex sleep-related behaviours associated with rapideye movement sleep behaviour disorder in Parkinson’s disease patients: a caseseries (PubMed)
- Cannabidiol for the treatment of psychosis in Parkinson’s disease (PubMed)
- Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ⁹-THCV in animal models of Parkinson’s disease (PubMed)
- Therapeutic potential of cannabinoids in CNS disease (PubMed)
- Effects of cannabidiol in the treatment of patients with Parkinson’s disease: an exploratory double-blind trial. (PubMed 2014)
- Dorsolateral Prefrontal Cortex N-Acetylaspartate/Total Creatine (NAA/tCr) Loss in Male Recreational Cannabis Users ( Research Gate/PubMed 2007)
- Cannabidiol for the treatment of psychosis in Parkinson’s disease. (PubMed 2008)
Prion/Mad Cow Disease:
PTSD:
- The endocannabinoid system provides an avenue for evidence-based treatment development for PTSD (PubMed)
- Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the world trade center attacks (PubMed)
- Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear (PubMed)
- Modulation of Fear Memory by Dietary Polyunsaturated Fatty Acids via Cannabinoid Receptors (PubMed)
- Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: Possible involvement of 5HT1A receptors (PubMed)
- Stress switches cannabinoid type-1 (CB1) receptor-dependent plasticity from LTD to LTP in the bed nucleus of the stria terminalis (PubMed)
- Mitigation of post-traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence (PubMed)
- Cannabinoid modulation of fear extinction brain circuits: A novel target to advance anxiety treatment (PubMed)
- The endocannabinoid system and extinction learning (PubMed)
- A current overview of cannabinoids and glucocorticoids in facilitating extinction of aversive memories: potential extinction enhancers (PubMed)
- Cannabinoids and traumatic stress modulation of contextual fear extinction and GR expression in the amygdala-hippocampal-prefrontal circuit (PubMed)
- Non-antidepressant long-term treatment in post-traumatic stress disorder (PubMed)
- The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: Involvement of the endocannabinoid system (PubMed)
- Modulation of Fear Memory by Dietary Polyunsaturated Fatty Acids via Cannabinoid Receptors (PubMed)
Rheumatism:
Schizophrenia:
- Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug (PubMed)
- Cannabidiol as a potential treatment for psychosis (PubMed)
- Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia (PubMed)
- Medical use of cannabis. Cannabidiol: A new light for schizophrenia? (PubMed)
- A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation (PubMed)
- Peripheral endocannabinoid system dysregulation in first-episode psychosis (PubMed)
- Cannabinoids and schizophrenia: Therapeutic prospects (PubMed)
- Antipsychotic-like effects of cannabidiol and rimonabant: Systematic review of animal and human studies (PubMed)
- Cannabidiol monotherapy for treatment-resistant schizophrenia (PubMed)
- Cannabis with high cannabidiol content is associated with fewer psychotic experiences (PubMed)
- Marijuana compound treats schizophrenia with few side effects: Clinical trial (Time)
- Clearing the smoke: what do we know about adolescent cannabis use and schizophrenia? (PubMed)
Sickle Cell Anaemia:
Skin Conditions :
- Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis (PubMed)
- Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes (PubMed)
- The endocannabinoid system of the skin in health and disease: Novel perspectives and therapeutic opportunities (PubMed)
- Epigenetic control of skin differentiation genes by phytocannabinoids (PubMed)
- A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ (PubMed)
- Endocannabinoids modulate human epidermal keratinocyte proliferation and survival via the sequential engagement of cannabinoid receptor-1 and transient receptor potential vanilloid-1 (PubMed)
- Cannabinoid 1 receptors in keratinocytes modulate proinflammatory chemokine secretion and attenuate contact allergic inflammation (PubMed)
- Attenuation of allergic contact dermatitis through the endocannabinoid system (PubMed)
- Topical cannabinoid agonists. An effective new possibility for treating chronic pruritus (PubMed)
Sleep Disorders:
- The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent (PubMed)
- Cannabis, pain, and sleep: Lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine (PubMed)
- Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats (PubMed)
- Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults (PubMed)
- Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats (PubMed)
- Endocannabinoid modulation of cortical up-states and NREM sleep (PubMed)
- Intranodose ganglion injections of dronabinol attenuate serotonin-induced apnea in Sprague-Dawley rat (PubMed)
Spinal Cord Injury :
Stress :
- Endogenous cannabinoid signaling is essential for stress adaptation (PubMed)
- Regulation of endocannabinoid signaling by stress: Implications for stress-related affective disorders (PubMed)
- Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output (PubMed)
- Neuromodulators, stress and plasticity: a role for endocannabinoid signalling (PubMed)
- Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress (PubMed)
- Endocannabinoids and stress (PubMed)
- Stress regulates endocannabinoid-CB1 receptor signaling (PubMed)
- Chronic Stress Impairs α1-Adrenoceptor-Induced Endocannabinoid-Dependent Synaptic Plasticity in the Dorsal Raphe Nucleus (Pub Med)
- Endocannabinoid-mediated modulation of stress responses: Physiological and pathophysiological significance (PubMed)
- Cannabinoid receptor activation prevents the effects of chronic mild stress on emotional learning and LTP in a rat model of depression (PubMed)
- Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory (PubMed)
- The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system (PubMed)
- Low-frequency stimulation evokes serotonin release in the nucleus accumbens and induces long-term depression via production of endocannabinoid (PubMed)
Stroke/TBI :
- Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury (PubMed)
- Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism (PubMed)
- Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism (PubMed)
- Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function (PubMed)
- Protective Effects of Cannabidiol Against Hippocampal Cell Death and Cognitive Impairment Induced by Bilateral Common Carotid Artery Occlusion in Mice (PubMed)
- Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance (PubMed)